1:33 p.m. EST, January 27, 2010

TEHRAN, Iran (AP) — Iran's supreme leader predicted the destruction of Israel in comments posted on his Web site on Wednesday, in some of his strongest remarks in years about the Jewish state.

In the past, Ayatollah Ali Khamenei has called Israel a "cancerous tumor" that must be wiped from the map, but the new comments mark the first time in years he has openly speculated about Israel's demise.

"Definitely, the day will come when nations of the region will witness the destruction of the Zionist regime," Khamenei was quoted as saying. "How soon or late (Israel's demise) will happen depends on how Islamic countries and Muslim nations approach the issue." He did not elaborate.